Student experiences of technology integration in school subjects: A comparison across four middle schools

This research examined student perspectives on their in-school, subject specific, technology use in four U.S. public schools. Considering students’ perspectives may provide a significant reframing of adult-created rhetoric of the utopian power of digital technologies for changing teaching and learning. A survey and focus group interviews were administered to 6th and 7th students (n=1,544) in four public middle schools, with varying demographics, that rely on local funding. These four schools revealed moderate use of many well-established digital technologies, such as word processing, presentation software, and quiz games. Students voiced outright hatred for teacher-directed PowerPoint-supported lectures, the most prominent technology activity students experienced, yet reported enjoying creation activities. The students in the rural school with a Hispanic-majority and high economically disadvantaged population reported much lower technology use. Discussion frame the digital inequities in the four schools and emphasizes the need for awareness and inclusion of students’ digital experiences to form any trajectory toward establishing digital equity and learning in schools

On the origin of the asymmetric dwarf galaxy distribution around Andromeda

The dwarf galaxy distribution surrounding M31 is significantly anisotropic in nature. Of the 30 dwarf galaxies in this distribution, 15 form a disc-like structure and 23 are contained within the hemisphere facing the Milky Way. Using a realistic local potential, we analyse the conditions required to produce and maintain these asymmetries. We find that some dwarf galaxies are required to have highly eccentric orbits in order to preserve the presence of the hemispherical asymmetry with an appropriately large radial dispersion. Under the assumption that the dwarf galaxies originate from a single association or accretion event, we find that the initial size and specific energy of that association must both be relatively large in order to produce the observed hemispherical asymmetry. However if the association was large in physical size, the very high-energy required would enable several dwarf galaxies to escape from the M31 and be captured by the Milky Way. Furthermore, we find that associations that result in this structure have total specific energies concentrated around $E = V_{esc}^{2} - V_{init}^{2} \sim 200^2$ -- $300^2\ \rm{km^2\ s^{-2}}$, implying that the initial velocity and initial position needed to produce the structure are strongly correlated. The overlap of initial conditions required to produce the radial dispersion, angular dispersion, and the planar structure is small and suggests that either they did not originate from a single accretion event, or that these asymmetric structures are short-lived.Comment: 12 pages, 10 figures, accepted by MNRA

Kinematics of the Tucana Dwarf Galaxy: an unusually dense dwarf in the Local Group

We present new FLAMES+GIRAFFE spectroscopy of 36 member stars in the isolated Local Group dwarf spheroidal galaxy Tucana. We measure a systemic velocity for the system of $v_{Tuc}$=216.7$^{+2.9}_{−2.8}$ km s$^{−1}$, and a velocity dispersion of σ$_{v,Tuc}$=14.4$^{+2.8}_{−2.3}$ km s$^{−1}$. We also detect a rotation gradient of $\frac{dvr}{dχ}$=7.6$^{+4.2}_{−4.3}$ km s$^{−1}$ kpc$^{−1}$, which reduces the systemic velocity to $v_{Tuc}$=215.2$^{+2.8}_{−2.7}$ km s$^{−1}$ and the velocity dispersion to σ$_{v,Tuc}$=13.3$^{+2.7}_{−2.3}$ km s$^{−1}$. We perform Jeans modelling of the density profile of Tucana, using the line-of-sight velocities of the member stars. We find that it favours a high central density consistent with ‘pristine’ subhaloes in Λ cold dark matter, and a massive dark matter halo (~10$^{10}$ M$_\odot$) consistent with expectations from abundance matching. Tucana appears to be significantly more centrally dense than other isolated Local Group dwarfs, making it an ideal laboratory for testing dark matter models

Andromeda XXV -- a dwarf galaxy with a low central dark matter density

Andromeda (And) XXV has previously been reported as a dwarf spheroidal galaxy (dSph) with little-to-no dark matter. However, the uncertainties on this result were significant. In this study, we double the number of member stars and re-derive the kinematics and mass of And XXV. We find that And XXV has a systemic velocity of $\nu_\mathrm{r}=-107.7\pm1.0 \mathrm{~km s}^{-1}$ and a velocity dispersion of $\sigma_\nu=4.5\pm1.0\mathrm{~km s}^{-1}$. With this better constrained velocity dispersion, we derive a mass contained within the half-light radius of $M(r< r_\mathrm{h})=6.9^{+3.2}_{-2.8}\times10^6\mathrm{~M}_\odot$. This mass corresponds to a mass-to-light ratio of $\mathrm{[M/L]}_\mathrm{r_\mathrm{h}}=37^{+17}_{-15}\mathrm{~M}_\odot/\mathrm{L}_\odot$, demonstrating, for the first time, that And XXV has an unambiguous dark matter component. We also measure the metallicity of And XXV to be $\mathrm{[Fe/H]}=-1.9\pm0.1$$\mathrm{~}$dex, which is in agreement with previous results. Finally, we extend the analysis of And XXV to include mass modelling using GravSphere. We find that And XXV has a low central dark matter density, $\rho_\mathrm{DM}(150\mathrm{pc})= 2.7^{+1.8}_{-1.6}\times10^7\mathrm{~M}_\odot\mathrm{kpc}^{-3}$, making And XXV a clear outlier when compared to other Local Group (LG) dSphs of the similar stellar mass. In a companion paper, we will explore whether some combination of dark matter cusp-core transformations and/or tides can explain And XXV's low density.Comment: 13 pages, 8 figures (7 main, 1 appendix). Submitted to MNRA

The Astropy Problem

The Astropy Project (http://astropy.org) is, in its own words, "a community effort to develop a single core package for Astronomy in Python and foster interoperability between Python astronomy packages." For five years this project has been managed, written, and operated as a grassroots, self-organized, almost entirely volunteer effort while the software is used by the majority of the astronomical community. Despite this, the project has always been and remains to this day effectively unfunded. Further, contributors receive little or no formal recognition for creating and supporting what is now critical software. This paper explores the problem in detail, outlines possible solutions to correct this, and presents a few suggestions on how to address the sustainability of general purpose astronomical software

Early pregnancy peripheral blood gene expression and risk of preterm delivery: a nested case control study

<p>Abstract</p> <p>Background</p> <p>Preterm delivery (PTD) is a significant public health problem associated with greater risk of mortality and morbidity in infants and mothers. Pathophysiologic processes that may lead to PTD start early in pregnancy. We investigated early pregnancy peripheral blood global gene expression and PTD risk.</p> <p>Methods</p> <p>As part of a prospective study, ribonucleic acid was extracted from blood samples (collected at 16 weeks gestational age) from 14 women who had PTD (cases) and 16 women who delivered at term (controls). Gene expressions were measured using the GeneChip^®Human Genome U133 Plus 2.0 Array. Student's T-test and fold change analysis were used to identify differentially expressed genes. We used hierarchical clustering and principle components analysis to characterize signature gene expression patterns among cases and controls. Pathway and promoter sequence analyses were used to investigate functions and functional relationships as well as regulatory regions of differentially expressed genes.</p> <p>Results</p> <p>A total of 209 genes, including potential candidate genes (e.g. PTGDS, prostaglandin D2 synthase 21 kDa), were differentially expressed. A set of these genes achieved accurate pre-diagnostic separation of cases and controls. These genes participate in functions related to immune system and inflammation, organ development, metabolism (lipid, carbohydrate and amino acid) and cell signaling. Binding sites of putative transcription factors such as EGR1 (early growth response 1), TFAP2A (transcription factor AP2A), Sp1 (specificity protein 1) and Sp3 (specificity protein 3) were over represented in promoter regions of differentially expressed genes. Real-time PCR confirmed microarray expression measurements of selected genes.</p> <p>Conclusions</p> <p>PTD is associated with maternal early pregnancy peripheral blood gene expression changes. Maternal early pregnancy peripheral blood gene expression patterns may be useful for better understanding of PTD pathophysiology and PTD risk prediction.</p

The Imaging X-ray Polarimetry Explorer (IXPE): Technical Overview

The Imaging X-ray Polarimetry Explorer (IXPE) will expand the information space for study of cosmic sources, by adding linear polarization to the properties (time, energy, and position) observed in x-ray astronomy. Selected in 2017 January as a NASA Astrophysics Small Explorer (SMEX) mission, IXPE will be launched into an equatorial orbit in 2021. The IXPE mission will provide scientifically meaningful measurements of the x-ray polarization of a few dozen sources in the 2-8 keV band, including polarization maps of several x-ray-bright extended sources and phase-resolved polarimetry of many bright pulsating x-ray sources

Transcriptional Responses of Cultured Rat Sympathetic Neurons during BMP-7-Induced Dendritic Growth

Dendrites are the primary site of synapse formation in the vertebrate nervous system; however, relatively little is known about the molecular mechanisms that regulate the initial formation of primary dendrites. Embryonic rat sympathetic neurons cultured under defined conditions extend a single functional axon, but fail to form dendrites. Addition of bone morphogenetic proteins (BMPs) triggers these neurons to extend multiple dendrites without altering axonal growth or cell survival. We used this culture system to examine differential gene expression patterns in naïve vs. BMP-treated sympathetic neurons in order to identify candidate genes involved in regulation of primary dendritogenesis.To determine the critical transcriptional window during BMP-induced dendritic growth, morphometric analysis of microtubule-associated protein (MAP-2)-immunopositive processes was used to quantify dendritic growth in cultures exposed to the transcription inhibitor actinomycin-D added at varying times after addition of BMP-7. BMP-7-induced dendritic growth was blocked when transcription was inhibited within the first 24 hr after adding exogenous BMP-7. Thus, total RNA was isolated from sympathetic neurons exposed to three different experimental conditions: (1) no BMP-7 treatment; (2) treatment with BMP-7 for 6 hr; and (3) treatment with BMP-7 for 24 hr. Affymetrix oligonucleotide microarrays were used to identify differential gene expression under these three culture conditions. BMP-7 significantly regulated 56 unique genes at 6 hr and 185 unique genes at 24 hr. Bioinformatic analyses implicate both established and novel genes and signaling pathways in primary dendritogenesis.This study provides a unique dataset that will be useful in generating testable hypotheses regarding transcriptional control of the initial stages of dendritic growth. Since BMPs selectively promote dendritic growth in central neurons as well, these findings may be generally applicable to dendritic growth in other neuronal cell types

Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans

Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in 25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16 regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP, while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium (LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region. Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa, an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent signals within the same regio

The development and validation of a scoring tool to predict the operative duration of elective laparoscopic cholecystectomy

Background: The ability to accurately predict operative duration has the potential to optimise theatre efficiency and utilisation, thus reducing costs and increasing staff and patient satisfaction. With laparoscopic cholecystectomy being one of the most commonly performed procedures worldwide, a tool to predict operative duration could be extremely beneficial to healthcare organisations. Methods: Data collected from the CholeS study on patients undergoing cholecystectomy in UK and Irish hospitals between 04/2014 and 05/2014 were used to study operative duration. A multivariable binary logistic regression model was produced in order to identify significant independent predictors of long (> 90 min) operations. The resulting model was converted to a risk score, which was subsequently validated on second cohort of patients using ROC curves. Results: After exclusions, data were available for 7227 patients in the derivation (CholeS) cohort. The median operative duration was 60 min (interquartile range 45–85), with 17.7% of operations lasting longer than 90 min. Ten factors were found to be significant independent predictors of operative durations > 90 min, including ASA, age, previous surgical admissions, BMI, gallbladder wall thickness and CBD diameter. A risk score was then produced from these factors, and applied to a cohort of 2405 patients from a tertiary centre for external validation. This returned an area under the ROC curve of 0.708 (SE = 0.013, p  90 min increasing more than eightfold from 5.1 to 41.8% in the extremes of the score. Conclusion: The scoring tool produced in this study was found to be significantly predictive of long operative durations on validation in an external cohort. As such, the tool may have the potential to enable organisations to better organise theatre lists and deliver greater efficiencies in care